Receptor acoplado à proteína G




Receptores acoplados às proteínas G são uma grande família proteica de receptores transmembranares que captam sinais extracelulares e activam vias de transdução de sinal no interior da célula. Este tipo de receptores apenas é encontrado nos eucariotas, como é o caso das leveduras, plantas, coanoflagelados,[1] e animais.


Os ligandos que se ligam e activam estes receptores incluem compostos sensíveis à luz, odores, feromonas, hormonas e neurotransmissores, e variam em tamanho, desde pequenas moléculas, até péptidos, podendo mesmo ser grandes proteínas.


Estes receptores estão envolvidos numa variedade de doenças, mas também são o alvo de cerca de metade das drogas medicinais humanas.[2]



Referências |




  1. ↑ King N, Hittinger CT, Carroll SB (2003). «Evolution of key cell signaling and adhesion protein families predates animal origins». Science. 301 (5631): 361-3. PMID 12869759. doi:10.1126/science.1083853  !CS1 manut: Nomes múltiplos: lista de autores (link)


  2. ↑ Filmore, David (2004). «It's a GPCR world». American Chemical Society. Modern Drug Discovery. 2004 (November): 24-28 





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