Receptor acoplado à proteína G




Receptores acoplados às proteínas G são uma grande família proteica de receptores transmembranares que captam sinais extracelulares e activam vias de transdução de sinal no interior da célula. Este tipo de receptores apenas é encontrado nos eucariotas, como é o caso das leveduras, plantas, coanoflagelados,[1] e animais.


Os ligandos que se ligam e activam estes receptores incluem compostos sensíveis à luz, odores, feromonas, hormonas e neurotransmissores, e variam em tamanho, desde pequenas moléculas, até péptidos, podendo mesmo ser grandes proteínas.


Estes receptores estão envolvidos numa variedade de doenças, mas também são o alvo de cerca de metade das drogas medicinais humanas.[2]



Referências |




  1. ↑ King N, Hittinger CT, Carroll SB (2003). «Evolution of key cell signaling and adhesion protein families predates animal origins». Science. 301 (5631): 361-3. PMID 12869759. doi:10.1126/science.1083853  !CS1 manut: Nomes múltiplos: lista de autores (link)


  2. ↑ Filmore, David (2004). «It's a GPCR world». American Chemical Society. Modern Drug Discovery. 2004 (November): 24-28 





Ícone de esboço
Este artigo sobre Bioquímica é um esboço relacionado ao Projeto Química. Você pode ajudar a Wikipédia expandindo-o.

  • v

  • d

  • e



-

Popular posts from this blog

A CLEAN and SIMPLE way to add appendices to Table of Contents and bookmarks

Image
0 I found a lot of questions abount appendices and ToC. Many users want appendices to be grouped in an Appendix part, however some problems arise with ToC, hyperref, PDF viewer bookmarks, and so on. There are different solutions which require extra packages, command patching and other extra code, however none of them satisfies me. I almost found an easy way to accomplish a good result, where appendices are added to bookmarks in the right way and hyperref links point to the right page. However, the number of the "Appendix" part page is wrong (it's the number of appendix A). Is there any EASY way to fix that? This is a MWE: documentclass{book} usepackage[nottoc,notlot,notlof]{tocbibind} usepackage{hyperref} begin{document} frontmatter tableofcontents mainmatter part{First} chapter{...
Read more

Calculate evaluation metrics using cross_val_predict sklearn

Image
1 In the sklearn.model_selection.cross_val_predict page it is stated: Generate cross-validated estimates for each input data point. It is not appropriate to pass these predictions into an evaluation metric. Can someone explain what does it mean? If this gives estimate of Y (y prediction) for every Y (true Y), why can't I calculate metrics such as RMSE or coefficient of determination using these results? python scikit-learn cross-validation share | improve this question edited Nov 28 '18 at 17:52 desertnaut 20.3k 7 43 79 ...
Read more

Insert data from modal to MySQL (multiple modal on website)

Image
0 I have problem with inserting data to MySQL from modal. My modal: <a href="#" class="badge badge-pill badge-success">6 komentarzy</a> <a href="#" class="badge badge-pill badge-danger">brak komentarzy</a> <a data-toggle="modal" href="#add_desk_comm_{$desk_['desk_id']}" data-target="#add_desk_comm_{$desk_['desk_id']}" class="ediiit">(dodaj)</a> <div class="modal fade" id="add_desk_comm_{$desk_['desk_id']}" tabindex="-1" role="dialog" aria-labelledby="edit_printer" aria-hidden="true"> <div class="modal-dialog" role="document"> ...
Read more